Intrauterine Insemination
Written by: Dr. Mohammed Agdi
Intrauterine Insemination (IUI) is a procedure used to assist patients in achieving a pregnancy. This procedure involves ovulation induction using tablets and injectable drugs until mature follicles develop then HCG injection is given to trigger final egg maturation and ovulation. Then, within 12-36 hours after HCG injection, the husband will be asked to produce a semen sample. The sample will be processed by our lab through a “sperm wash” technique that separates mobile sperm from non-mobile sperm and other cellular debris present in the ejaculate. Most of the fluid will also be washed off, resulting in a highly concentrated specimen of sperm. Within an hour or two of semen preparation your doctor will use a small catheter to place the washed sperms into the uterus. This process does not cause any discomfort, does not need any sedation or anesthesia. At least one fallopian tube must be open because after being placed into the uterus the sperm must swim the length of the fallopian tube and fertilize the egg at the distal end of the fallopian tube. The goal of the IUI procedure is to present a high concentration of motile sperm into the uterus to facilitate the union of an egg with a sperm in the fallopian tubes. The IUI procedure can be used in a number of different situations. Some examples are:
• Patients with unexplained infertility
• Patients with slightly low sperm concentration or motility
• Patients with thick cervical mucus or any other conditions involving the cervix.
The process of ovarian stimulation is similar as ovulation induction described previously.
Cancellation of the Cycle - Canceling the cycle (not giving the HCG or doing intercourse) can prevent OHSS and multiple pregnancies. At times, this may be the safest way to proceed. Cycles may also be canceled for inadequate response.
The earliest pregnancy test can be done is 14 days after the HCG was given. Please call the treatment coordinator to communicate your result of pregnancy test.
If pregnancy occurs, you need to continue on the luteal support medications with the same dose and frequency till 12 weeks or otherwise recommended by your physician. Subsequently, a follow-up visit for pregnancy ultrasound will be arranged.
If pregnancy test is negative, you need to arrange a follow-up visit to see your physician for further discussion of future plan and recommendation.
Frequency of Therapy: 3-4 cycles
Informed Consent for the treatment is essential and has to be completed by both husband and wife.